SOLAS_Sensitivity_Analysis.png

 

 

 

 

Old methods of treating missing data, such as LOCF, are now being robustly challenged by global regulators. It is clear from recent FDA, NRC & ICH documentation that a new approach to missing data is going to be required. Increasingly multiple imputation is seen as offering a strong solution.

Tipping point analysis is novel approach to examining sensitivity analysis around the imputed missing data. This tipping point approach was used in advisory committee meetings with the FDA and has already been instrumental in gaining approval for a medical device (Liublinska, V. and Rubin, D.B. (2014)).

 View 10 Min SOLAS Tipping Point Demo

 

SOLAS Sensitivity Analysis now offers Tipping Point Plots. 

SOLAS_Sensitivity_Analysis_Image_1.png 

Click Plot for Interpretation Explanation

Compare imputed data that has been generated using several different MI methods.